Big Pharma Ramps Up M&A, Licensing Deals Amid Declining Drug Development Returns

Technology|
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By Woo Seung-ho, Park Se-eun (Intern)
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AI PRISM: Personalized Economic Briefing

*Editor's Note: 'AI PRISM' (Personalized Report & Insight Summarizing Media) is an AI-based personalized news recommendation and summary service developed with support from the Korea Press Foundation. It selects and provides six customized news items for each reader type.*

Key Issue Briefing

Big Pharma M&A Rush: Global pharmaceutical companies are significantly expanding mergers and acquisitions and technology licensing in response to soaring drug development costs and declining productivity. Open innovation is becoming an industry standard, with Pfizer acquiring Metsera for $10 billion and Johnson & Johnson acquiring Intra-Cellular Therapies for $14.6 billion.

LNG Boom and Contrarian Investment: While restructuring pressures sweep across the petrochemical industry, Kumho Petrochemical is investing 140 billion won to expand MDI production capacity, backed by more than 1 trillion won in cash. As demand surges for MDI, a key raw material for LNG carrier insulation, the company is making a preemptive capacity expansion move in a market dominated by six players.

AI Infrastructure Investment Accelerates: SoftBank, led by Chairman Masayoshi Son, acquired DigitalBridge, an AI infrastructure investment firm specializing in data centers and fiber optic networks, for $4 billion. The acquisition of DigitalBridge, which manages approximately $108 billion in assets, is expected to strengthen next-generation AI data center capabilities.

Startup Founder News

1. Big Pharma Expands M&A, Technology Licensing Amid Declining Drug Development Returns

Global big pharma companies are significantly expanding M&A and technology licensing in response to declining drug development profitability. In the second half of this year, Pfizer acquired Metsera for $10 billion to secure obesity drug candidates, Johnson & Johnson acquired Intra-Cellular Therapeutics for $14.6 billion, and Novartis acquired Avidity Biosciences for $12 billion. According to the Korea Pharmaceutical and Bio-Pharma Manufacturers Association, global drug development costs rose 78% from $1.4 billion in 2014 to $2.5 billion in 2020, while clinical trial periods extended from 6.15 years to 7.14 years.

2. Kumho Petrochemical Escapes Restructuring, Expands Investment Riding LNG Boom

While restructuring pressures sweep across the petrochemical industry, Kumho Petrochemical is expanding investment by riding the LNG super cycle. Its subsidiary Kumho Mitsui Chemicals will invest 140 billion won to add 100,000 tons of production capacity for MDI (methylene diphenyl diisocyanate), a key polyurethane raw material. Kumho Petrochemical maintains a net cash position with negative net debt of 81.7 billion won as of the end of Q3, holding 1.1015 trillion won in cash and cash equivalents, and recorded free cash flow of 331.3 billion won, demonstrating ample investment capacity.

3. Business Sentiment Index Hits 17-Month High on U.S. Capital Investment Expansion

Corporate sentiment rose for two consecutive months to reach its highest level in one year and five months. According to the Bank of Korea's December business survey, the all-industry Composite Business Sentiment Index (CBSI) rose 1.6 points from the previous month to 93.7, the highest since July last year (95.5). Manufacturing CBSI reached 94.4, positively influenced by expanding demand for machinery and equipment related to U.S. capital investment, while non-manufacturing also rose to 93.2 amid the year-end peak season. Notably, export companies' CBSI outlook for January next year reached 98.1, the highest level since September 2022 (99.7).

Startup Founder Reference News

4. Will AI Replace Future Doctors? Medical School Admission Quota Caught in Variables

AI has emerged as a key issue in the process of estimating "future doctor shortages," which will serve as the core basis for determining medical school admission quotas for the 2027 academic year. The Physician Workforce Supply and Demand Estimation Committee projected doctor supply at 133,000 and demand at 142,000 to 169,000 by 2040, but the shortage estimate varies more than twofold, ranging from 10,000 to 36,000. Some committee members believe doctor demand will increase due to reduced per-capita workload from work-life balance preferences and physician aging, while others believe the number of doctors needed will decrease as AI enables each doctor to treat more patients.

5. No KakaoTalk After Work: Government to Regulate 'Inclusive Wage' System Enabling Unpaid Overtime

The Ministry of Employment and Labor announced a roadmap to reduce actual working hours to the OECD average of 1,700 hours annually by 2030. Key measures include legislating the "right to disconnect," allowing employees to refuse work communications via KakaoTalk after work hours, and amending the Labor Standards Act to prevent abuse of the inclusive wage system that enables unpaid overtime. The plan also includes support for companies adopting flexible commuting, remote work, and 4.5-day workweeks, institutionalizing half-day annual leave usage, and designating Labor Day as a public holiday.

6. SoftBank Acquires AI Infrastructure Firm DigitalBridge for $4 Billion

SoftBank Group, led by Chairman Masayoshi Son, acquired DigitalBridge, an AI infrastructure investment firm, for approximately $4 billion (about 5.7 trillion won). SoftBank will acquire all outstanding shares of DigitalBridge at $16 per share, reflecting a 15% premium over the December 26 closing price. DigitalBridge is an asset management firm investing in AI and digital infrastructure including data centers, fiber optic networks, and wireless base stations, with assets under management of approximately $108 billion (about 156.22 trillion won) as of the end of September. "As AI transforms industries worldwide, more computing, connectivity, power, and infrastructure are needed," Chairman Son said, outlining his vision to strengthen next-generation AI data center capabilities and become an artificial superintelligence (ASI) platform provider.

Original reporting by Woo Seung-ho, Park Se-eun (Intern) for Seoul Economic Daily.

AI-translated from Korean. Quotes from foreign sources are based on Korean-language reports and may not reflect exact original wording.

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